The Substance Cast: Full List of Actors & Characters
Explore the main performers in The Substance (2024), plus a quick look at the drama, horror, and sci-fi elements that make the film stand out.
If you’re trying to track down who brought The Substance to life, this guide gives you the key names and why they matter. The 2024 film blends drama, horror, and sci-fi into a sharp, unsettling story, and its performances are a big part of what makes it stick with viewers. We focus on the main ensemble behind the movie, with an eye on the characters and the creative energy they bring to the screen.
About the Show
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Full Cast
- Demi Moore
- Margaret Qualley
- Dennis Quaid
- Edward Hamilton-Clark
- Gore Abrams
- Oscar Lesage
- Christian Erickson
- Robin Greer
Created By
- Coralie Fargeat
Where to Watch
You can stream The Substance on: Max
More Information
This page is built to help you quickly understand the people behind The Substance and how their performances support the film’s mix of drama, horror, and sci-fi. Whether you’re checking details before watching or revisiting the movie afterward, you’ll find a clear starting point here. Bookmark this page if you want an easy reference, and come back anytime you need a refresher. It’s updated regularly so the information stays useful as new details become available.
Frequently Asked Questions
Where can I watch The Substance?
The Substance is currently streaming on Max.
Who stars in The Substance?
The cast includes Demi Moore, Margaret Qualley, Dennis Quaid, Edward Hamilton-Clark, Gore Abrams.
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Last updated: September 8, 2026